Retinoic Acid Is a Potent Regulator of Growth Plate Chondrogenesis
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چکیده
منابع مشابه
Retinoic acid is a potent regulator of growth plate chondrogenesis.
Vitamin A deficiency and excess both cause abnormalities in mammalian longitudinal bone growth. Because all-trans retinoic acid (RA) is synthesized from vitamin A, we hypothesized that RA regulates growth plate chondrogenesis. Consistent with this hypothesis, a single oral dose of RA reduced the height of the rat proximal tibial growth plate. To determine whether RA acts directly on growth plat...
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Matrix extracellular phosphoglycoprotein (MEPE) belongs to the SIBLING protein family which play key roles in biomineralization. Although the growth plates of MEPE-overexpressing mice display severe morphological disruption, the expression and function of MEPE in growth plate matrix mineralization remains largely undefined. Here we show MEPE and its cleavage product, the acidic serine aspartate...
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Biomineralization is a highly regulated process that plays a major role during the development of skeletal tissues. Despite its obvious importance, little is known about its regulation. Previously, it has been demonstrated that retinoic acid (RA) stimulates terminal differentiation and mineralization of growth plate chondrocytes (Iwamoto, M., I.M. Shapiro, K. Yagumi, A.L. Boskey, P.S. Leboy, S....
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The role of the cellular retinoic acid binding protein type II (CRABPII) in the retinoic acid (RA) signaling pathway is poorly understood. Northern blot analysis of 12 breast cell lines showed that CRABPII mRNA content correlated with growth inhibition by RA, suggesting that this binding protein enhances cellular response to RA. Ectopic CRABPII expression supported dose-dependent growth inhibit...
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INTRODUCTION Retinoic acid (RA) and its derivatives play vital roles in the regulation of growth, differentiation, and morphogenesis. During development, several roles have been proposed for RA, including anterior-posterior patterning of the limb, promotion of neural crest outgrowth and survival, and promotion of neurite outgrowth. Traditionally, research in the retinoid field has focused prima...
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ژورنال
عنوان ژورنال: Endocrinology
سال: 2000
ISSN: 0013-7227
DOI: 10.1210/en.141.1.346